Silanes and Siloxanes for Sythetics and Pharmaceuticals

The field of organosilicon chemistry has undergone explosive growth in the past thirty years, organosilicon compounds have many applications in organic chemistry, most notably as:

		Derivatization reagents
		Blocking / Protective agents
		Intermediates in organic synthesis
		Reducing agents.

Silylating Agents

Silylating agents are reagents that are used to replace the active hydrogen of a chemical species with a silyl group (-Si RR'R"). In general, the replacement of active hydrogens significantly decreases the reactivity of a functional group and dramatically reduces polar interactions such as hydrogen bonding. These replacements can: (1) Protect a reactive functional group during one or more chemical reactions (2) Improve the selectivity of a chemical reaction (3) Improve stability during distillation (4) Improve solubility in polar and/or non-polar solvents (5) Increase volatility by reducing or eliminating hydrogen-bonding

Reducing Agents

Hydrosilanes and hydrosiloxanes such as triethylsilanes, triisopropylsilane and 1,1,3,3-tetramethyldisiloxane are highly selective reducing agents for the reduction of carbon-carbon and carbon-heteroatom multiple bonds, as well as carbon-hydroxy and carbon-halogen single bonds.

Blocking / Protective Agents

Organosilyl Bloking Agents (Protective Agents) are widely used in organic synthesis especially in syntheses of drugs for most of them can be get easily , have a steady property , easy to use and can be get rid off in very mild conditions. And in most of these cases, Silane Blocking Agent can protect/ deprotect functional groups selectively. It is has become a novel method for improving the process and enhancing the quality of the products in syntheses of drugs. Silane Blocking Agents (Protective Agents) are widely used in the syntheses including semi-synthesis and total synthesis of prostaglandins, 7-ADCA which is a intermediate of cephalosporin, Taxol which is a new anticance drug and Acylovir-a novel antivius drug.

		Trimethylsilyl Blocking Agents
		Trialkylsilyl Blocking Agents
		Phenyl-Containing Blocking Agents
		Specialty Silicon-Based Blocking Agents
		Bridging Silicon-Based Blocking Agents